HIST2H2BF

HIST2H2BF is a human gene that encodes for a histone protein. Histones are basic nuclear proteins responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around an octamer of histone proteins. This octamer is composed of two copies each of H2A, H2B, H3, and H4.

HIST2H2BF specifically encodes for histone H2B type 2-F. Histone H2B variants play a crucial role in various cellular processes, including chromatin structure regulation, DNA replication, DNA repair, and transcriptional regulation. The specific functions of HIST2H2BF are still being investigated, but it is known to be involved in nucleosome assembly and stability. Different H2B variants exhibit distinct expression patterns and post-translational modifications, suggesting specialized roles in gene regulation and chromatin organization. Studies have shown that alterations in HIST2H2BF expression or function can be associated with certain diseases, highlighting the importance of this histone variant in maintaining genomic integrity and proper cellular function. The gene is located on chromosome 6.