FOLFOX

FOLFOX is an acronym representing a chemotherapy regimen used to treat colorectal cancer. It is a combination therapy that typically includes the following drugs:

• FOL: Folinic acid (Leucovorin), a form of folate that enhances the effect of fluorouracil.
• F: Fluorouracil (5-FU), an antimetabolite that interferes with DNA and RNA synthesis, inhibiting cancer cell growth.
• OX: Oxaliplatin, a platinum-based drug that damages DNA, preventing cancer cells from replicating.

FOLFOX is usually administered intravenously, and the specific dosage and schedule are determined by the oncologist based on the individual patient's characteristics, stage of cancer, and overall health. It is often used as an adjuvant therapy after surgery to remove the primary tumor, aiming to eradicate any remaining cancer cells and reduce the risk of recurrence. It can also be used as a neoadjuvant therapy before surgery to shrink the tumor. Potential side effects of FOLFOX can include nausea, vomiting, diarrhea, fatigue, peripheral neuropathy (nerve damage causing tingling or numbness in the hands and feet), and myelosuppression (bone marrow suppression leading to low blood cell counts).