Cefcapene

Cefcapene is an orally administered cephalosporin antibiotic. It belongs to the class of beta-lactam antibiotics and is characterized by its broad spectrum of activity against a variety of Gram-positive and Gram-negative bacteria. Cefcapene is often administered as the pivoxil ester, cefcapene pivoxil hydrochloride hydrate, which is a prodrug. The ester group enhances oral absorption and is then hydrolyzed in the body to release the active form, cefcapene.

Cefcapene's mechanism of action involves inhibiting bacterial cell wall synthesis. It binds to penicillin-binding proteins (PBPs), which are essential enzymes involved in the peptidoglycan synthesis pathway, ultimately leading to bacterial cell death.

Cefcapene is used to treat a range of bacterial infections, including respiratory tract infections such as pneumonia and bronchitis, as well as skin and soft tissue infections. Its use is generally reserved for infections resistant to other commonly prescribed antibiotics, or when other options are unsuitable.

Common side effects associated with cefcapene include gastrointestinal disturbances such as nausea, vomiting, and diarrhea. Allergic reactions are also possible, as with other beta-lactam antibiotics. As with all antibiotics, cefcapene use can contribute to the development of antibiotic resistance.

Cefcapene is typically available as tablets or granules for oral suspension. Dosage and duration of treatment vary depending on the severity and type of infection, as well as patient factors.