CSNK2B

CSNK2B, also known as Casein Kinase II Subunit Beta, is a human gene that encodes the regulatory subunit beta of the protein kinase CK2 (formerly known as casein kinase II). CK2 is a ubiquitous and pleiotropic serine/threonine kinase involved in various cellular processes, including cell cycle control, DNA repair, apoptosis, and signal transduction.

The protein encoded by the CSNK2B gene forms a heterotetrameric enzyme complex with the catalytic subunits alpha and/or alpha'. The regulatory beta subunit is essential for the stability and activity of the holoenzyme. It plays a crucial role in substrate recognition and the modulation of kinase activity. The beta subunit can also function independently of the catalytic subunits in some cellular contexts.

Variations in the CSNK2B gene have been associated with various developmental disorders and neurological conditions. Research suggests a role for CSNK2B in regulating neuronal development and synaptic plasticity. Aberrant expression or mutations in CSNK2B may disrupt these processes, contributing to disease phenotypes.

The CSNK2B gene is located on chromosome 6p21.31 in humans. It is widely expressed across different tissues.

Further research continues to explore the diverse functions of CSNK2B and its involvement in human health and disease.