BRL-54443

BRL-54443 is a research chemical belonging to the indoleamine class. It is an analogue of melatonin and is classified as a selective melatonin receptor agonist, specifically demonstrating high affinity for both the MT1 and MT2 receptors.

While research on BRL-54443 is limited compared to more established melatonin receptor agonists like melatonin itself or ramelteon, studies have investigated its potential effects on circadian rhythm regulation, sleep, and other physiological processes mediated by melatonin receptors. Research suggests that BRL-54443 may exhibit a longer half-life and greater potency than melatonin.

Due to its primarily experimental nature, BRL-54443 is not currently approved for medical use in humans and is primarily used in scientific research to study the role of melatonin receptors in various biological functions. Its potential therapeutic applications are still being explored. Data on long-term safety and efficacy in humans is lacking.

The IUPAC name for BRL-54443 is N-[2-(3-methoxyphenyl)ethyl]-2-(5-methoxy-1H-indol-3-yl)ethanamine.

Because BRL-54443 is a research chemical, it is often subject to legal restrictions depending on jurisdiction. Its possession, sale, and use may be controlled or prohibited.