A-84,543

A-84,543 is a research chemical classified as a potent and selective α7 nicotinic acetylcholine receptor (nAChR) agonist. It belongs to the chemical family of diaryl ethers and is structurally related to other α7 nAChR agonists.

As an agonist, A-84,543 binds to and activates α7 nAChRs, which are ligand-gated ion channels that play a role in various cognitive processes, including learning, memory, and attention. Activation of these receptors can lead to increased calcium influx and downstream signaling cascades within neurons.

A-84,543 has been investigated in preclinical studies for its potential therapeutic applications in neurological and psychiatric disorders characterized by cognitive deficits, such as Alzheimer's disease, schizophrenia, and age-related cognitive decline. Research has explored its ability to enhance cognitive performance, improve attention, and modulate neurotransmitter release.

The pharmacological profile of A-84,543 includes high affinity and selectivity for α7 nAChRs, minimizing its interaction with other nicotinic receptor subtypes and other receptors, potentially reducing the likelihood of off-target effects. However, like many research chemicals, its effects and safety profile in humans are not fully understood, and further research is required to determine its clinical utility. It is primarily used in laboratory research settings and is not approved for human medical use.