(+)-epi-alpha-bisabolol synthase

(+)-epi-alpha-bisabolol synthase is an enzyme involved in the biosynthesis of (+)-epi-alpha-bisabolol, a monocyclic sesquiterpenoid alcohol. This enzyme belongs to the terpene synthase family, specifically those that catalyze the cyclization and modification of farnesyl pyrophosphate (FPP) or its structural analog, geranylgeranyl pyrophosphate (GGPP).

The primary function of (+)-epi-alpha-bisabolol synthase is to convert FPP into (+)-epi-alpha-bisabolol. The reaction typically involves a series of steps, including ionization of FPP, cyclization to form a carbocation intermediate, and subsequent rearrangement and deprotonation to generate the final product.

The enzyme's activity and specificity are crucial for regulating the production of (+)-epi-alpha-bisabolol in various organisms, particularly plants. (+)-epi-alpha-bisabolol is known for its potential pharmacological properties, including anti-inflammatory, antimicrobial, and antioxidant activities. Therefore, understanding the structure, function, and regulation of (+)-epi-alpha-bisabolol synthase is of interest in both plant biochemistry and pharmaceutical research.

The gene encoding (+)-epi-alpha-bisabolol synthase has been identified and characterized in several plant species. Its expression can be influenced by various developmental and environmental factors. Research has also focused on the enzyme's catalytic mechanism and the structural features that determine its product specificity.

(+)-epi-alpha-bisabolol synthase can be used in biotechnological applications for the production of (+)-epi-alpha-bisabolol, either through direct extraction from plant sources or through microbial fermentation using genetically engineered microorganisms expressing the enzyme.