mir-143

mir-143 is a human microRNA (miRNA). MicroRNAs are small, non-coding RNA molecules that function in RNA silencing and post-transcriptional regulation of gene expression. They are typically 21-23 nucleotides in length and bind to the 3' untranslated region (3'UTR) of target messenger RNAs (mRNAs), leading to mRNA degradation or translational repression.

Mir-143 has been implicated in various biological processes, including cell proliferation, differentiation, and apoptosis. Its expression patterns are often dysregulated in various diseases, particularly in cancers, where it can act as either an oncogene or a tumor suppressor depending on the specific context and target mRNAs.

Research suggests that mir-143 plays a role in smooth muscle cell function and cardiovascular disease. It has also been investigated for its potential involvement in metabolic disorders and inflammatory responses. Further research is ongoing to fully elucidate the functions and regulatory networks involving mir-143 in different tissues and disease states.