SMARCD1

SMARCD1, also known as BAF60a, is a gene that encodes a protein subunit of the SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin subfamily d member 1 (SMARCD1) protein complex. This complex, often referred to as the BAF complex in mammals and the SWI/SNF complex in yeast, is involved in chromatin remodeling. Chromatin remodeling is a critical process for regulating gene expression, DNA repair, and DNA replication.

The SMARCD1 protein functions as a core component of the BAF complex, contributing to its stability and function. It plays a role in facilitating the complex's interaction with DNA and other chromatin-associated proteins. Through its involvement in chromatin remodeling, SMARCD1 influences a wide range of cellular processes, including cell growth, differentiation, and development.

Mutations or aberrant expression of the SMARCD1 gene have been implicated in various human diseases, including certain types of cancer and developmental disorders. Research continues to explore the precise mechanisms by which SMARCD1 and the BAF complex contribute to these conditions. Studies focus on identifying the specific genes regulated by SMARCD1 and understanding how disruptions in its function lead to disease pathology.

The study of SMARCD1 is significant for gaining insights into the fundamental mechanisms of gene regulation and chromatin remodeling. Further research into the roles of SMARCD1 and the BAF complex has the potential to lead to the development of novel therapeutic strategies for diseases associated with their dysregulation.