RHOBTB3

RHOBTB3 (Rho-related BTB domain-containing protein 3) is a human gene that encodes a protein belonging to the RhoBTB family of atypical Rho GTPases. This protein family is characterized by the presence of an N-terminal Rho GTPase domain, followed by a Broad complex, Tramtrack, and Bric-a-brac (BTB) domain and a C-terminal BACK (BTB-associated C-terminal kelch) domain.

The RHOBTB3 protein is thought to play a role in various cellular processes, including cytoskeletal organization, cell growth, and cell differentiation. While the precise function of RHOBTB3 is still under investigation, the presence of the Rho GTPase domain suggests it may regulate downstream signaling pathways involved in these processes. The BTB domain is often involved in protein-protein interactions and ubiquitin ligase complex formation, hinting at potential roles in transcriptional regulation or protein degradation. The BACK domain interacts with Kelch repeat domains, implying involvement in substrate recognition for ubiquitin ligase activity.

RHOBTB3 has been implicated in certain human diseases, with some studies suggesting a possible link to neurodevelopmental disorders and certain types of cancer. Research is ongoing to further elucidate the precise role of RHOBTB3 in both normal cellular function and disease pathogenesis. Genetic variants of RHOBTB3 may contribute to disease susceptibility or severity. Understanding the function and regulation of RHOBTB3 is crucial for developing potential therapeutic strategies for related diseases.