HT1080

HT1080 is a fibrosarcoma cell line derived from human connective tissue. It is known for its high degree of malignancy and its ability to form tumors in immunocompromised mice. The cell line is commonly used in cancer research as a model to study tumor growth, metastasis, and response to various therapeutic agents.

Specifically, HT1080 cells are often employed in investigations related to matrix metalloproteinases (MMPs) and their role in tumor invasion and angiogenesis. These cells produce and secrete MMPs, enzymes that degrade the extracellular matrix, facilitating tumor spread.

Furthermore, HT1080 cells are relatively easy to culture and transfect, making them a useful tool for genetic manipulation and gene expression studies in the context of cancer biology. Their well-characterized properties and widespread availability have made them a standard cell line in many research laboratories worldwide.