Christian Lüscher (neurobiologist)

Christian Lüscher is a Swiss neuroscientist and professor known for his research on synaptic plasticity, reward learning, and the neurobiological basis of addiction. He is a professor at the University of Geneva, where he heads a research group in the Department of Basic Neurosciences.

Lüscher's work has significantly contributed to our understanding of the molecular mechanisms underlying synaptic changes associated with learning and memory, particularly in the context of reward and addiction. His research utilizes a combination of electrophysiological, optogenetic, and behavioral techniques to investigate how drugs of abuse alter synaptic circuits in the brain, leading to compulsive drug-seeking behavior.

Specifically, Lüscher has made important discoveries regarding the role of long-term potentiation (LTP) and long-term depression (LTD) in drug-induced synaptic plasticity. He has also explored the involvement of specific receptors and signaling pathways in mediating these plastic changes. His research has implicated the glutamatergic system and dopamine signaling in the development and maintenance of addiction.

Lüscher's research has implications for the development of novel therapeutic strategies for treating addiction and other neuropsychiatric disorders. He is a highly cited researcher in the field of neuroscience and has received numerous awards for his contributions to the understanding of brain function and disease. He is also active in public outreach, communicating scientific findings to a broader audience.