WRNIP1

WRNIP1 (Werner Helicase Interacting Protein 1) is a human gene encoding a protein that interacts with the Werner syndrome ATP-dependent helicase (WRN). WRNIP1 is involved in DNA replication and repair processes.

Function:

The WRNIP1 protein is thought to play a role in maintaining genomic stability by interacting with WRN, a key protein involved in DNA replication, recombination, and repair. This interaction is crucial for proper DNA processing. It is suggested that WRNIP1 modulates the activity of WRN and/or recruits WRN to specific sites of DNA damage or replication stress. Studies suggest WRNIP1 is involved in the cellular response to DNA damage, particularly during replication. It can also influence the DNA damage checkpoint response.

Structure:

WRNIP1's protein structure contains domains that facilitate protein-protein interactions, allowing it to bind to WRN and other cellular components. Specific details of its secondary and tertiary structure are still being investigated.

Clinical Significance:

Aberrant expression or mutations in WRNIP1 have been implicated in cancer development and progression. Its involvement in DNA repair pathways makes it a potential therapeutic target for cancer treatment strategies aimed at exploiting DNA damage response vulnerabilities. Further research is necessary to fully understand its role in various diseases and its potential as a therapeutic target.

Interactions:

WRNIP1 is known to interact with Werner syndrome ATP-dependent helicase (WRN). Other interacting proteins are still being investigated. These interactions are essential for its function in DNA repair and replication processes.

Further Research:

Ongoing research is focused on elucidating the precise molecular mechanisms by which WRNIP1 functions, its role in different types of cancer, and its potential as a target for therapeutic intervention.