Tiapamil

Tiapamil is a calcium channel blocker that was investigated as a potential antiarrhythmic and antianginal agent. Chemically, it is a phenylalkylamine derivative, similar to verapamil. Research on Tiapamil was conducted primarily in the latter half of the 20th century. While it showed some promise in preclinical and early clinical studies, it did not achieve widespread use or regulatory approval in many countries. Its effects include reducing myocardial contractility, slowing heart rate, and dilating coronary arteries. Its mechanism of action involves blocking the influx of calcium ions into cardiac and vascular smooth muscle cells. Further research and development were limited due to factors such as the emergence of other calcium channel blockers with more favorable profiles and potential side effects observed during clinical trials. Tiapamil is not commonly used in modern clinical practice.