GPR111

GPR111 is a human gene that encodes a G protein-coupled receptor (GPCR). It is also known as Adhesion G protein-coupled receptor G1 (ADGRG1), and previously as PGR4 (Progesterone receptor-related gene 4).

As a member of the adhesion GPCR family, GPR111/ADGRG1 is characterized by a large N-terminal extracellular region. This region contains various protein domains predicted to mediate cell adhesion and protein-protein interactions. The exact function of GPR111/ADGRG1 remains under investigation, but adhesion GPCRs are known to be involved in diverse physiological processes, including cell migration, cell signaling, immune responses, and development.

Specific tissues where GPR111/ADGRG1 is expressed vary depending on the study and method of detection. Research suggests expression in several tissues, including the brain, immune cells, and other organ systems, indicating a potentially wide range of biological roles.

The ligands and signaling pathways associated with GPR111/ADGRG1 are not fully elucidated. Like other GPCRs, activation of GPR111/ADGRG1 is expected to trigger intracellular signaling cascades via G proteins. Further research is needed to identify the specific ligands that bind to GPR111/ADGRG1 and the downstream signaling pathways that are activated upon receptor stimulation.

Mutations or dysregulation of GPR111/ADGRG1 may contribute to various disease states; however, current evidence linking GPR111/ADGRG1 to specific diseases is limited and warrants further investigation.