SLC22A13

SLC22A13, also known as Organic Anion Transporter 13 (OAT13), is a protein encoded by the SLC22A13 gene in humans. It belongs to the Solute Carrier 22A (SLC22A) family of transmembrane proteins, a family known for its diverse roles in transporting organic ions across cellular membranes.

While the precise substrate specificity and physiological function of SLC22A13 are not fully elucidated, research suggests it is involved in the transport of specific organic anions. Studies have indicated a potential role in the renal handling of urate, a key factor in gout. Specifically, the protein's localization to the kidney supports the hypothesis that it participates in the reabsorption or secretion of urate within the renal tubules.

Genetic variations within the SLC22A13 gene have been investigated for their potential association with serum urate levels and the risk of gout. However, conclusive evidence establishing a strong and consistent link remains a subject of ongoing research. Other potential substrates and tissue distribution beyond the kidney are also under investigation to gain a more comprehensive understanding of the protein's biological significance.

The SLC22A13 gene is located on chromosome 11 in humans. Further research is necessary to fully characterize the substrates transported by SLC22A13, its precise cellular localization in various tissues, and its overall contribution to human physiology and disease.