ZMYND10

ZMYND10 is a human gene that encodes for a protein also named ZMYND10. This protein is a zinc finger, MYND-type containing 10. ZMYND10 is implicated in ciliogenesis, the process of creating cilia, cellular organelles crucial for a variety of functions including cell signaling, motility, and sensory perception.

Function:

The primary function of ZMYND10 is related to the formation and function of cilia. It is believed to play a role in the assembly and maintenance of intraflagellar transport (IFT) complexes, which are essential for building and maintaining cilia and flagella. Disruption of ZMYND10 function leads to defects in ciliogenesis and subsequent cellular dysfunction.

Associated Diseases:

Mutations in the ZMYND10 gene have been linked to primary ciliary dyskinesia (PCD), a rare genetic disorder that affects the function of cilia lining the respiratory tract, fallopian tubes, and flagella of sperm. PCD is characterized by chronic respiratory infections, infertility, and sometimes situs inversus (a reversal of the internal organs).

Structure:

The ZMYND10 protein contains a MYND (MYeloid Nervy DEAF-1) domain, also known as a SPOC (Spt3-PTA1-Orphan Copressor) domain. This domain is a protein-protein interaction domain often found in transcriptional repressors. The protein also contains zinc finger motifs, which are DNA-binding domains.

Interactions:

ZMYND10 interacts with other proteins involved in ciliogenesis and IFT, but the specific nature and significance of all these interactions are still under investigation. Understanding these interactions is crucial for fully elucidating the role of ZMYND10 in ciliary function and the pathogenesis of PCD.