RASSF8

RASSF8 (Ras association domain-containing family member 8) is a protein-coding gene in humans. It belongs to the Ras association (RalGDS/AF-6) family of tumor suppressor genes, specifically the RASSF subfamily. These genes are involved in a variety of cellular processes including cell growth, apoptosis, and microtubule stabilization.

RASSF8 is thought to function as a regulator of cell polarity and trafficking, potentially through its interaction with other proteins involved in these processes. Research suggests that RASSF8 may play a role in the development and progression of certain cancers, although its precise function and mechanisms of action are still under investigation.

The RASSF8 protein contains a Ras-association domain, which allows it to interact with Ras GTPases, a family of proteins involved in cell signaling. Through these interactions, RASSF8 can influence downstream signaling pathways that regulate cell growth and survival.

Dysregulation of RASSF8 expression or function has been implicated in various diseases, including cancer. Aberrant methylation of the RASSF8 promoter region, leading to gene silencing, has been observed in some tumor types. Further research is needed to fully elucidate the role of RASSF8 in normal cellular function and in the pathogenesis of disease.

The gene encoding RASSF8 is located on chromosome 12.