JWH-307

JWH-307 is a synthetic cannabinoid that belongs to the naphthoylindole family. It acts as a potent CB1 receptor agonist, meaning it binds to and activates the CB1 receptor in the brain and other parts of the body. This receptor is part of the endocannabinoid system, which plays a role in regulating various physiological processes including mood, appetite, pain sensation, and immune function.

JWH-307, like other synthetic cannabinoids, was originally developed for research purposes to study the endocannabinoid system. However, it gained notoriety as a recreational drug, often sold as a component of "spice" or "K2," herbal mixtures that are smoked. The use of JWH-307 and similar synthetic cannabinoids has been associated with adverse health effects, including anxiety, paranoia, psychosis, tachycardia, vomiting, and seizures. These effects are often more severe and unpredictable compared to those associated with cannabis.

The sale and possession of JWH-307, along with many other synthetic cannabinoids, have been outlawed in numerous countries due to their potential for abuse and harmful effects. Its chemical name is 5-(2-chlorophenyl)-1-pentyl-1H-indol-3-yl-(1-naphthyl)methane. Its effects and risks are important areas of ongoing research.