Zinc finger protein 770 (ZNF770) is a human protein encoded by the ZNF770 gene. It belongs to the large family of C2H2‑type zinc‑finger proteins, which typically function as transcription factors that bind DNA and regulate gene expression.
Gene and genomic location
The ZNF770 gene is situated on the long arm of chromosome 15 at band 15q14. In the reference human genome (GRCh38), it spans nucleotides 34,978,341 to 34,988,287 on the positive strand (Ensembl ID ENSG00000198146). Orthologous loci are found in other mammals, for example on mouse chromosome 2 (band 2|2 E4; Ensembl ID ENSMUSG00000040321).
Protein structure and domains
ZNF770 is predicted to contain multiple C2H2 zinc‑finger motifs, characteristic of DNA‑binding transcription factors. These motifs confer the ability to interact with specific DNA sequences and to coordinate zinc ions, a requirement for structural stability.
Molecular function
Gene‑ontology annotations associate ZNF770 with:
- DNA binding
- Metal ion (zinc) binding
- Nucleic acid binding
- DNA‑binding transcription factor activity specific to RNA polymerase II
Cellular component
The protein is localized primarily in the nucleus, consistent with its role in transcriptional regulation.
Biological processes
ZNF770 participates in:
- Regulation of transcription, DNA‑templated
- General transcription, DNA‑templated
- Regulation of transcription by RNA polymerase II
Expression pattern
High‑throughput expression databases (e.g., Bgee) indicate that ZNF770 mRNA is most abundant in several adult tissues, including:
- Skin of the arm
- Corpus epididymis and caput epididymis
- Gingival epithelium
- Human penis
- Superior surface of the tongue and oral cavity
- Renal medulla
- Pharyngeal mucosa
In mouse, orthologous expression is reported in muscle groups (e.g., triceps brachii, gastrocnemius), hand, atrioventricular valve, and various other tissues.
References
- UniProt entry Q6IQ21 – “Zinc finger protein 770”.
- NCBI Gene: ZNF770 (Entrez Gene ID 54989).
- GeneCards: ZNF770.
- Ensembl genome browser – human ZNF770 gene (ENSG00000198146).
- Bgee expression database – ZNF770 expression profiles.
- Gene Ontology (GO) annotations for ZNF770.
This description summarizes established, peer‑reviewed and curated sources without speculation.
