White Shirt Creek is a stream in the U.S. state of South Dakota. It is located in Corson County, near the town of McIntosh, South Dakota. The stream's name derives from Chief Fred White Shirt, a member of the Sioux (Lakota) tribe. The geographic coordinates are approximately 45°44′31″N 101°15′04″W.
The creek is classified as a physical feature (stream class) and falls within the 8-digit Hydrologic Unit Code (HUC) 10130303 watershed. It has been monitored as a water quality site by the U.S. Environmental Protection Agency's National Aquatic Resources Survey (NARS).