Piscopo is an Italian surname.
- Etymology: The surname "Piscopo" derives from the Italian word piscopo, meaning "bishop." This, in turn, comes from the Latin episcopus, and ultimately from the Greek episkopos (ἐπίσκοπος), meaning "overseer" or "guardian." It may have originated as a nickname for someone resembling a bishop, someone in service to a bishop, or for a former church official.
- Notable People:
- Joe Piscopo (born 1951), an American comedian, actor, and radio talk show host. He is best known for his work as a cast member on the NBC sketch comedy show Saturday Night Live from 1980 to 1984, where he became popular for his impressions of celebrities such as Frank Sinatra and David Letterman. He also starred in films such as Johnny Dangerously (1984) and Wise Guys (1986).