Oosterhuis established himself through his distinctive approach to documenting the Dutch landscape, often capturing the beauty and engineering marvels of the country's coastal areas, flood defenses, and industrial sites. He is especially recognized for his comprehensive photographic documentation of the Delta Works, an ambitious series of construction projects in the Netherlands designed to protect vast areas of land from the sea and river flooding. His images frequently explore themes of human intervention in nature, the sublime scale of engineering, and the ever-changing Dutch environment.
Throughout his career, Oosterhuis has published several photography books, showcasing his unique perspective and thematic depth. His work has been exhibited in various galleries and cultural institutions, contributing significantly to the visual narrative of the Dutch landscape and its intricate relationship with human engineering. Beyond his practice as a professional photographer, Oosterhuis is also involved in photography education, sharing his knowledge and experience through workshops and courses.