PPP1R27 (Protein Phosphatase 1 Regulatory Subunit 27) is a protein-coding gene in humans that encodes a regulatory subunit of protein phosphatase 1 (PP1). It is also known by the alias DYSFIP1.
Gene and Protein Information
- Gene ID: 116729 (NCBI)
- Chromosomal Location: Chromosome 17 at band 17q25.3 (human)
- Genomic Coordinates: 81,833,492 – 81,835,050 bp (human)
- Protein: UniProt ID Q86WC6
- Aliases: PPP1R27, DYSFIP1
Function
PPP1R27 encodes a protein that functions as a regulatory subunit of protein phosphatase 1 (PP1). It contains ankyrin repeat domains and exhibits phosphatase binding activity. The protein is involved in the negative regulation of catalytic activity, modulating PP1-mediated dephosphorylation events in cellular signaling pathways.
Expression
According to RNA expression data, PPP1R27 is most highly expressed in skeletal muscle tissues (including muscle of thigh, gastrocnemius muscle, and soleus muscle), as well as in the pituitary gland, bone marrow, and adrenal glands. In mouse models, expression is also prominent in various muscle groups and the otolith organ.
Orthologs
PPP1R27 is evolutionarily conserved, with identified orthologs in mice (gene 68701, chromosome 11) and at least 255 orthologues and 3 paralogues across species.
External Resources
- Wikipedia: PPP1R27
- GeneCards: PPP1R27
- UniProt: Q86WC6
- NCBI Gene: 116729
- Ensembl: ENSG00000182676
