Marie-Anne Waldstein (1763–1808), also referred to as Maria Anna von Waldstein-Wartenberg, was a prominent noblewoman of the late 18th and early 19th centuries. Born into the aristocratic Waldstein family of Bohemia, she was the daughter of Count Emanuel Philibert von Waldstein-Wartenberg and Princess Maria Anna of Liechtenstein.
In 1781, she married José Gabriel de Silva-Bazán y Waldstein, the 10th Marquess of Santa Cruz. Through this marriage, she became a significant figure in the Spanish court and was known by the title of Marchioness of Santa Cruz.
Historical records identify her as a woman of significant intellectual and artistic interest. She was an amateur painter and a patron of the arts, leading to her appointment as an honorary member and counselor of the Real Academia de Bellas Artes de San Fernando in Madrid.
She is widely recognized in the field of art history as the subject of a portrait painted by Francisco de Goya. The portrait, titled The Marchioness of Santa Cruz (c. 1797–1798), is considered a notable example of Goya's work during his period as a court painter, reflecting the Enlightenment-era styles favored by the Spanish aristocracy. Waldstein remained a notable presence in Spanish high society until her death in 1808.