The following is a list of songs that reached number one on the Italian Singles Chart during 2015, as compiled by Federazione Industria Musicale Italiana (FIMI). FIMI releases a weekly chart of the top-selling singles in Italy, based on sales and streaming data.
| Date (Issue Date) | Song Title | Artist(s) |
|---|---|---|
| January 1 | Uptown Funk | Mark Ronson featuring Bruno Mars |
| January 8 | Uptown Funk | Mark Ronson featuring Bruno Mars |
| January 15 | Uptown Funk | Mark Ronson featuring Bruno Mars |
| January 22 | Uptown Funk | Mark Ronson featuring Bruno Mars |
| January 29 | Uptown Funk | Mark Ronson featuring Bruno Mars |
| February 5 | Uptown Funk | Mark Ronson featuring Bruno Mars |
| February 12 | Uptown Funk | Mark Ronson featuring Bruno Mars |
| February 19 | Uptown Funk | Mark Ronson featuring Bruno Mars |
| February 26 | Take Me to Church | Hozier |
| March 5 | Take Me to Church | Hozier |
| March 12 | Take Me to Church | Hozier |
| March 19 | Take Me to Church | Hozier |
| March 26 | Take Me to Church | Hozier |
| April 2 | Cheerleader (Felix Jaehn Remix) | OMI |
| April 9 | Cheerleader (Felix Jaehn Remix) | OMI |
| April 16 | Cheerleader (Felix Jaehn Remix) | OMI |
| April 23 | Cheerleader (Felix Jaehn Remix) | OMI |
| April 30 | Cheerleader (Felix Jaehn Remix) | OMI |
| May 7 | Cheerleader (Felix Jaehn Remix) | OMI |
| May 14 | Cheerleader (Felix Jaehn Remix) | OMI |
| May 21 | Cheerleader (Felix Jaehn Remix) | OMI |
| May 28 | Cheerleader (Felix Jaehn Remix) | OMI |
| June 4 | Cheerleader (Felix Jaehn Remix) | OMI |
| June 11 | Cheerleader (Felix Jaehn Remix) | OMI |
| June 18 | Cheerleader (Felix Jaehn Remix) | OMI |
| June 25 | Cheerleader (Felix Jaehn Remix) | OMI |
| July 2 | Cheerleader (Felix Jaehn Remix) | OMI |
| July 9 | Cheerleader (Felix Jaehn Remix) | OMI |
| July 16 | El Perdón | Nicky Jam and Enrique Iglesias |
| July 23 | El Perdón | Nicky Jam and Enrique Iglesias |
| July 30 | El Perdón | Nicky Jam and Enrique Iglesias |
| August 6 | El Perdón | Nicky Jam and Enrique Iglesias |
| August 13 | El Perdón | Nicky Jam and Enrique Iglesias |
| August 20 | El Perdón | Nicky Jam and Enrique Iglesias |
| August 27 | El Perdón | Nicky Jam and Enrique Iglesias |
| September 3 | El Perdón | Nicky Jam and Enrique Iglesias |
| September 10 | El Perdón | Nicky Jam and Enrique Iglesias |
| September 17 | El Perdón | Nicky Jam and Enrique Iglesias |
| September 24 | El Perdón | Nicky Jam and Enrique Iglesias |
| October 1 | El Perdón | Nicky Jam and Enrique Iglesias |
| October 8 | El Perdón | Nicky Jam and Enrique Iglesias |
| October 15 | What Do You Mean? | Justin Bieber |
| October 22 | What Do You Mean? | Justin Bieber |
| October 29 | Hello | Adele |
| November 5 | Hello | Adele |
| November 12 | Hello | Adele |
| November 19 | Hello | Adele |
| November 26 | Hello | Adele |
| December 3 | Hello | Adele |
| December 10 | Hello | Adele |
| December 17 | Hello | Adele |
| December 24 | Hello | Adele |
| December 31 | Hello | Adele |