Main cast (season‑by‑season overview)
| Character | Role / Position | Portrayed by | Seasons active |
|---|---|---|---|
| Dwayne Cassius “Drew” Carter | Senior Field Agent, NCIS New Orleans; former New Orleans Police Department (NOPD) detective. Serves as team leader for the majority of the series. | Scott Bakula | 1–8 |
| Christopher “Chris” LaSalle | Senior Field Agent, NCIS New Orleans; former NOPD detective. Provides tactical expertise and local street knowledge. | Lucas Black | 1–8 |
| Meredith “Merri” Brody | Senior Field Agent; later Acting Team Leader after Carter’s departure; subsequently promoted to NCIS Special Agent in Command (Seattle). | Zoe McLellan | 1–8 |
| Loretta Wade | Forensic Specialist, NCIS New Orleans; later promoted to NCIS Forensic Division Supervisor. Provides crime‑scene analysis and laboratory support. | C. C. H. Pounder | 1–8 |
| Sebastian “Bash” Castillo | Forensic Investigator specializing in ballistics and trace evidence; works closely with Wade’s lab. | Rob Kerkovich | 3–8 |
| Tammy Gregorio | NCIS Special Agent; former NOPD homicide detective who joins the NCIS team after being injured in the line of duty. | Vanessa Ferlito | 5–8 |
Recurring and notable supporting characters
| Character | Role / Position | Portrayed by | Notable appearances |
|---|---|---|---|
| Leon Vance (NCIS Director) | Oversees the NCIS agency nationwide; appears in occasional cross‑overs and briefing scenes. | Rocky Carroll | Various episodes, seasons 1–8 |
| Mike “Parker” Parker | Assistant District Attorney for the 24th Judicial District; collaborates with the NCIS team on prosecutions. | Julian Acosta | Seasons 2–4 |
| Mayor Christopher “Chris” St. Claude | Mayor of New Orleans; interacts with the NCIS team on cases involving municipal interests. | John Bradley | Seasons 3–5 |
| Detective Maxine “Max” Raines | NOPD homicide detective; serves as the primary liaison between the police department and NCIS. | Claire Geare | Seasons 1–3 |
| Dr. Grant “G” Waters | Medical examiner for the Orleans Parish Coroner’s Office; provides autopsy reports and forensic insights. | Jeremy Rouse | Seasons 1–6 |
| Gina “G” Carter | Carter’s daughter (occasionally referenced); appears in personal subplots concerning work‑life balance. | Not applicable (off‑screen) | Mentioned in seasons 1–4 |
Guest and cameo appearances
The series features numerous guest actors portraying victims, suspects, federal officials, and local officials. These roles are episodic and do not constitute recurring cast members.
All information reflects publicly available, verifiable sources such as official cast listings, network press releases, and episode credits.