Fryxell is a Swedish surname. Notable individuals with this surname include:
- Anders Fryxell (1795–1881), a prominent Swedish historian, clergyman, and educator. He is best known for his extensive work Berättelser ur svenska historien (Stories from Swedish History), a multi-volume historical narrative that covered Swedish history from ancient times up to the reign of King Charles XIV John. Fryxell was a member of the Swedish Academy and played a significant role in shaping the historical understanding of his time.
- Elizabeth Fryxell, an American chemist and entrepreneur. She is known for her work in synthetic biology and bioengineering, particularly her contributions to the development of genetically modified organisms for agricultural and industrial applications. Fryxell held key positions at companies such as DuPont and was a co-founder of Genomatica, a biotechnology company.