The Cox Building is a historic commercial building located in Maysville, Kentucky. Constructed in 1888, it is a prominent example of late 19th-century architecture in the downtown area. The building's design incorporates elements of Victorian commercial architecture, including ornate detailing and a cast-iron facade. It is known for its intricate cornice work and the well-preserved original storefronts on the ground floor.
The Cox Building has served a variety of commercial purposes throughout its history, housing retail businesses, offices, and other establishments. It has played a significant role in the economic and social life of Maysville. The building is recognized as a contributing property to the Maysville Downtown Historic District, which is listed on the National Register of Historic Places. Its presence helps to define the historic character of the downtown streetscape.