Barillas may refer to:
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Barillas (surname): A Spanish surname. Notable people with this surname include:
- José Barillas (disambiguation): Several people share this name. Often refers to José María Barillas, President of Guatemala from 1885 to 1892.
- Other individuals: Other individuals bearing this surname may be notable in various fields such as sports, politics, or the arts. Further research is needed to identify specific individuals.
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San Mateo Barillas: A municipality in the department of Huehuetenango, Guatemala. It is commonly referred to simply as "Barillas". The area is known for its indigenous Mayan population and rural setting.