Amphissa, in Greek mythology, was a daughter of Macareus of Lesbos. Her name is primarily known due to her association with Apollo. According to some accounts, she bore Apollo a son named Isthmus, the eponym of the Isthmian Games. Information about her beyond this parentage is scarce, and she is a relatively minor figure within the broader spectrum of Greek myths and legends. She appears mainly within genealogical accounts tracing the lineage of figures connected to Isthmus and the Isthmian Games.
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