The 2022 Sofia Open was a professional men's tennis tournament played on indoor hard courts. It was the seventh edition of the Sofia Open and was part of the ATP Tour 250 series of the 2022 ATP Tour. The tournament took place at the Arena Armeec in Sofia, Bulgaria, from September 26 to October 2, 2022.
Marc-Andrea Hüsler won the singles title, defeating Holger Rune in the final. This marked Hüsler's first ATP Tour singles title. In the doubles competition, Rafael Matos and David Vega Hernández claimed the championship, triumphing over Jason Kubler and John Peers in the final.