The 2021 XPEL 375 was an NTT IndyCar Series event held on May 2, 2021, at Texas Motor Speedway in Fort Worth, Texas, United States. It was the fourth race of the 2021 NTT IndyCar Series season. The event was part of a unique doubleheader weekend at Texas Motor Speedway, with the Genesys 300 taking place the day before on May 1.
The race was contested over 248 laps on the 1.5-mile (2.4 km) high-banked oval. As the second race of the doubleheader, it followed the Genesys 300, making it the only time in the 2021 season that IndyCar raced on consecutive days at the same track. Scott Dixon, driving for Chip Ganassi Racing, won the XPEL 375, marking his second victory of the 2021 season and his fifth career victory at Texas Motor Speedway. The event's title sponsor was XPEL Inc., a company specializing in protective films and coatings for automotive and other applications.