The 2018 Texas Southern Tigers football team represented Texas Southern University in the 2018 NCAA Division I Football Championship Subdivision (FCS) season. The Tigers competed as members of the West Division of the Southwestern Athletic Conference (SWAC). Home games were played at BBVA Compass Stadium in Houston, Texas.
The team began the season under head coach Johnnie Cole, who was in his third year at the position. Cole was relieved of his duties on October 8, 2018, after an 0–5 start to the season; the remainder of the campaign was led by interim head coach (name not confirmed in available sources). The Tigers finished the season with an overall record of 2–9, including a 1–6 record in conference play, placing them near the bottom of the SWAC West Division standings.
